Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear
نویسندگان
چکیده
منابع مشابه
Aging-associated exacerbation in fatty degeneration and infiltration after rotator cuff tear.
BACKGROUND Rotator cuff tears are one of the most common musculoskeletal complaints and a substantial source of morbidity in elderly patients. Chronic cuff tears are associated with muscle atrophy and an infiltration of fat to the area, a condition known as "fatty degeneration." To improve the treatment of cuff tears in elderly patients, a greater understanding of the changes in the contractile...
متن کاملInhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice
Fatty infiltration in muscle is often observed in patients with sizable rotator cuff tear (RCT) and is thought to be an irreversible event that significantly compromises muscle plasticity and contraction strength. These changes in the mechanical properties of the affected muscle render surgical repair of RCT highly formidable. Therefore, it is important to learn more about the pathology of fatt...
متن کاملT lymphocytes are not required for the development of fatty degeneration after rotator cuff tear
OBJECTIVES Rotator cuff tears are among the most common and debilitating upper extremity injuries. Chronic cuff tears result in atrophy and an infiltration of fat into the muscle, a condition commonly referred to as 'fatty degeneration'. While stem cell therapies hold promise for the treatment of cuff tears, a suitable immunodeficient animal model that could be used to study human or other xeno...
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BACKGROUND Fatty infiltration in skeletal muscle is directly linked to loss of muscle strength and is associated with various adverse physical outcomes such as muscle atrophy, inflammation, insulin resistance, mobility impairments, and even mortality in the elderly. Aging, mechanical unloading, muscle injury, and hormonal imbalance are main causes of muscle fat accumulation, and the fat cells a...
متن کاملMassive rotator cuff tear.
Anthony A. Romeo, MD, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois. B C A A 72-year-old woman presents with chronic shoulder pain subsequent to a fall that has not responded to conservative treatment. She tells you that she “wants it fixed.” T2-weighted coronal (A) and sagittal (B) and T1-weighted sagittal (C) magnetic resonance images are provided. What ...
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ژورنال
عنوان ژورنال: Journal of Shoulder and Elbow Surgery
سال: 2014
ISSN: 1058-2746
DOI: 10.1016/j.jse.2013.04.011